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31
2024.10
"How to Run a Successful Intership Programme" - Professor Karki's interview on N…
Professor Karki recently contributed to an article featured on Nature, where they shared insights on…2024.10.31
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2024.08
A recent publication has been released. (Immunological Reviews)
Title : DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeu…2024.08.20
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11
2024.07
A new publication has been released! (Archives of Pharmacal Research)
A recent publication has been released.Title : Implications of inflammatory cell death-PANoptos…2024.07.11
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29
2024.02
A new publication has been released (Nature Communications)
A recent publication has been released.Title : NINJ1 mediates inflammatory cell death, PANoptosis, a…2024.02.29
Welcome to
Laboratory of Innate Immunity and Cell Death
Our laboratory is dedicated to investigating the vital role of innate immune responses in controlling various inflammatory, infectious, metabolic disorders, and cancer. Host cells play a crucial role in detecting molecular patterns associated with pathogens (PAMPs) and damage-related molecular patterns (DAMPs).
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage and mortality in SARS-CoV-2 infection and cytokine shock syndromes Karki R., Sharma B.R., Tuladhar S., Williams E.P., et al. (2021).
Cell 184:149–168.
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Diverging inflammasome signals in tumorigenesis and potential targeting Karki R.,Kanneganti T.D. (2019)
Nature reviews. Cancer 19:197–214.
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IRF8 regulates transcription of Naips for NLRC4 inflammasome activation Karki R., Lee E., Place D., et al. (2018).
Cell 173:1–14.
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NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer Karki R., Man S.M., Malireddi R.K., et al. (2016).
Nature 540:583–587.
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ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection Karki R., Lee S., Mall R., et al. (2022).
Science Immunology 7:eabo6294
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ADAR1 restricts ZBP1–mediated immune response and PANoptosis to promote tumorigenesis Karki R., Sundaram B., Sharma B.R., Lee S., Malireddi R.K.S., Nguyen L.N., Christgen S., Zheng M., Wang Y., Samir P., Neale G., Vogel P., Kanneganti T.D. (2021).
Cell reports 37:109858
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