-
13
2025.11
Professor Karki named Highly Cited Researcher 2025 in Immunology — for the secon…
We are delighted to share the wonderful news that Professor Karki has been selected once again for C…2025.11.13
-
13
2025.10
Our Lab in the News!
Our latest research papers have been making waves, and a few media outlets have picked up the story.…2025.10.13
-
11
2025.09
A recent publication has been released. (Cell Chemical Biology)
A new paper has been published, and it will also be featured on the cover of the journal. Congrats!T…2025.09.11
-
17
2025.06
Our Lab in the News!
Our latest research papers have been making waves, and a few media outlets have picked up the story.…2025.06.17
Welcome to
Laboratory of Innate Immunity and Cell Death
Our laboratory is dedicated to investigating the vital role of innate immune responses in controlling various inflammatory, infectious, metabolic disorders, and cancer. Host cells play a crucial role in detecting molecular patterns associated with pathogens (PAMPs) and damage-related molecular patterns (DAMPs).
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage and mortality in SARS-CoV-2 infection and cytokine shock syndromes Karki R., Sharma B.R., Tuladhar S., Williams E.P., et al. (2021).
Cell 184:149–168.
MORE VIEW
Diverging inflammasome signals in tumorigenesis and potential targeting Karki R.,Kanneganti T.D. (2019)
Nature reviews. Cancer 19:197–214.
MORE VIEW
IRF8 regulates transcription of Naips for NLRC4 inflammasome activation Karki R., Lee E., Place D., et al. (2018).
Cell 173:1–14.
MORE VIEW
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer Karki R., Man S.M., Malireddi R.K., et al. (2016).
Nature 540:583–587.
MORE VIEW
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection Karki R., Lee S., Mall R., et al. (2022).
Science Immunology 7:eabo6294
MORE VIEW
ADAR1 restricts ZBP1–mediated immune response and PANoptosis to promote tumorigenesis Karki R., Sundaram B., Sharma B.R., Lee S., Malireddi R.K.S., Nguyen L.N., Christgen S., Zheng M., Wang Y., Samir P., Neale G., Vogel P., Kanneganti T.D. (2021).
Cell reports 37:109858
MORE VIEW