"Galactosaminogalactan activates the inflammasome to provide host protection"

Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD., Nature, 2020 Dec, 588(7839), 688-692

"RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis"

R K Subbarao Malireddi, Sannula Kesavardhana, Rajendra Karki, Balabhaskararao Kancharana, Amanda R Burton, Thirumala-Devi Kanneganti, ImmunoHorizons, 2020 Dec, 4(12), 789-796

"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)"

Shelbi Christgen, Min Zheng 1, Sannula Kesavardhana 1, Rajendra Karki 1, R K Subbarao Malireddi 1, Balaji Banoth 1, David E Place 1, Benoit Briard 1, Bhesh Raj Sharma 1, Shraddha Tuladhar 1, Parimal Samir 1, Amanda Burton 1, Thirumala-Devi Kanneganti 1, Frontiers in Cellular and Infection Microbiology, 2020 May, 10:237,

"Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection"

Min Zheng, Evan Peter Williams, R K Subbarao Malireddi, Rajendra Karki, Balaji Banoth, Amanda Burton, Richard Webby, Rudragouda Channappanavar, Colleen Beth Jonsson, Thirumala-Devi Kanneganti, Journal of Biological Chemistry, 2020 Oct, 295(41), 14040-14052

"Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer"

Rajendra Karki, Bhesh Raj Sharma, Ein Lee, Balaji Banoth, R K Subbarao Malireddi, Parimal Samir, Shraddha Tuladhar, Harisankeerth Mummareddy, Amanda R Burton, Peter Vogel, Thirumala-Devi Kanneganti, JCI Insight, 2020 Jun, 5(12), e136720

"ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)"

Balaji Banoth, Shraddha Tuladhar, Rajendra Karki, Bhesh Raj Sharma, Benoit Briard, Sannula Kesavardhana, Amanda Burton, Thirumala-Devi Kanneganti, Journal of Biological Chemistry, Dec 25, 295(52), 18276-18283

"Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense"

Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti, Cell, 2020 Apr, 181(3), 674-687

"DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome"

Parimal Samir #, Sannula Kesavardhana #, Deanna M Patmore #, Sebastien Gingras, R K Subbarao Malireddi, Rajendra Karki, Clifford S Guy, Benoit Briard, David E Place, Anannya Bhattacharya, Bhesh Raj Sharma, Amanda Nourse, Sharon V King, Aaron Pitre, Amanda, Nature, 2019 Sep, 573(7775), 590-594

"Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging"

Hanzhi Luo, Wei-Chieh Mu, Rajendra Karki, Hou-Hsien Chiang, Mary Mohrin, Jiyung J Shin, Rika Ohkubo, Keisuke Ito, Thirumala-Devi Kanneganti, Danica Chen, Cell Reports, 2019 Jan, 26(4), 945-954

"Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice"

Bhesh Raj Sharma, Rajendra Karki, Ein Lee, Qifan Zhu, Prajwal Gurung, Thirumala-Devi Kanneganti, Cell Death and Differentiation, 2019 Mar, 26(4), 741-750

"Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection"

Benoit Briard, Rajendra Karki, R K Subbarao Malireddi, Anannya Bhattacharya, David E Place, Jayadev Mavuluri, Jennifer L Peters, Peter Vogel, Masahiro Yamamoto, Thirumala-Devi Kanneganti, Nature Microbiology, 2019 Feb, 4(2), 316-327

"Role of AIM2 inflammasome in inflammatory diseases, cancer and infection"

Bhesh Raj Sharma, Rajendra Karki, Thirumala-Devi Kanneganti, European Journal of Immunology, 2019 Nov, 49(11), 1998-2011

"Diverging inflammasome signals in tumorigenesis and potential targeting"

Rajendra Karki, Thirumala-Devi Kanneganti, Nature Reviews Cancer, 2019 Apr, 19(4), 197-214

"ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming"

David E Place, Parimal Samir, Rajendra Karki, Benoit Briard, Peter Vogel, Thirumala-Devi Kanneganti, American Journal of Pathology, 2018 Apr, 188(4), 1021-1030

"Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis"

Deepika Sharma, Ankit Malik, Clifford S Guy, Rajendra Karki 1, Peter Vogel 2, Thirumala-Devi Kanneganti 3, Gastroenterology, 2018 Mar, 154(4), 948-964