The innate immune system serves as a pivotal guardian, not only safeguarding the body against pathogens but also intricately regulating metabolic functions and inflammatory responses. Inflammation, a core component of the immune system's defense, has emerged as a significant factor in various metabolic conditions, including obesity, diabetes, atherosclerosis, and a spectrum of inflammatory disorders.
Beyond their conventional roles in instigating inflammation or cellular demise, these innate immune sensors display a broader influence on these conditions. Our primary focus revolves around untangling the intricate connections interlinking innate immunity, metabolic irregularities, and inflammatory diseases.