Laboratory of Innate Immunity and Cell Death Research


  • Innate Immunity in Metabolic and Inflammatory Diseases

    The innate immune system serves as a pivotal guardian, not only safeguarding the body against pathogens but also intricately regulating metabolic functions and inflammatory responses. Inflammation, a core component of the immune system's defense, has emerged as a significant factor in various metabolic conditions, including obesity, diabetes, atherosclerosis, and a spectrum of inflammatory disorders.

    Beyond their conventional roles in instigating inflammation or cellular demise, these innate immune sensors display a broader influence on these conditions. Our primary focus revolves around untangling the intricate connections interlinking innate immunity, metabolic irregularities, and inflammatory diseases.

  • Related Publications

    • - NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer , Karki R.; Man S.M.; Malireddi R.K.S.; Kesavardhana S.; Zhu Q.; Burton A.R.; Sharma B.R.; Qi X.; Pelletier S.; Vogel P.; Rosenstiel P.; Kanneganti T.-D., Nature, 2016 Dec 22;540(7634):583-587.